Products
MAPKBP1 antibody
- Product Name
- MAPKBP1 antibody
- Catalogue No.
- FNab05000
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- mitogen-activated protein kinase binding protein 1
- Alternative Names
- JNKBP1 antibody, KIAA0596 antibody
- UniProt ID
- O60336
- Observed MW
- 165 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:200 - 1:500; IHC: 1:50 - 1:100
Validated Images
mouse liver tissue were subjected to SDS PAGE followed by western blot with FNab05000(MAPKBP1 antibody) at dilution of 1:300
Immunohistochemistry of paraffin-embedded human stomach using FNab05000(MAPKBP1 antibody) at dilution of 1:100
- Background
- MAP kinases play a significant role in many biological processes, including cell adhesion and spreading, cell differentiation and apoptosis. MAPKBP-1 (mitogen-activated protein kinase binding protein 1), also known as JNKBP-1, is a 1, 514 amino acid protein that contains twelve WD repeats. Induced by TRAF2 (TNF receptor-associated factor 2) and Tak1 (TGF-β-activated kinase 1), MAPKBP-1 is thought to act an adaptor protein for NFκB (nuclear factor κ-B) activation. MAPKBP-1 interacts with JNK3 and may promote TRAF2 polyubiquitination. MAPKBP-1 exists as six alternatively spliced variants and is encoded by a gene located on human chromosome 15. Human chromosome 15 houses over 700 genes and comprises nearly 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes.
