anti- KLHL12 antibody

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Product Information
Product name

anti- KLHL12 antibody

Alternative name

C3IP1 antibody, KLHL12 Antibody

Catalogue No.

FNab04610

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Description

KLHL12 antibody: Rabbit Polyclonal antibody to KLHL12

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)

Background

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR (KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR (KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B) . As part of the BCR (KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR (KLHL12) complex also mediates polyubiquitination of DRD4, without leading to degradation of DRD4.

Immunogen Information
Immunogen

kelch-like 12 (Drosophila)

Synonyms

C3IP1

Calculated MW

53-56 kDa, 63-67 kDa

Application
Specificity

Human, Mouse, Rat

Tested Application

ELISA, WB, IHC, IF

Uniprot information
Gene Name

KLHL12

Uniprot ID

Q53G59

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Service

Hotline

027-87384275
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