rat liver tissue were subjected to SDS PAGE followed by western blot with FNab09769(IRS2 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded mouse stomach using FNab09769(IRS2 antibody) at dilution 1:100
Background
This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.