Products

INSR antibody

Synonyms:CD220 antibody, HHF5 antibody, INSR antibody, insulin receptor antibody, Insulin receptor beta antibody, IR antibody
Catalogue No.:FNab04336Reativity:Human, Mouse, Rat
Host:RabbitTested Application:ELISA, WB, IHC
Clonality:polyclonalIsotype:IgG
  • SPECIFICATIONS
Product Name
INSR antibody
Catalogue No.
FNab04336
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
insulin receptor
Alternative Names
CD220 antibody, HHF5 antibody, INSR antibody, insulin receptor antibody, Insulin receptor beta antibody, IR antibody
UniProt ID
P06213
Observed MW
135 kDa, 95 kDa, 190 kDa
Application
Tested Applications
ELISA, WB, IHC
Recommended dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Validated Images
various lysates were subjected to SDS PAGE followed by western blot with FNab04336(INSR antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded mouse liver using FNab04336(INSR antibody) at dilution of 1:50
Background
This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants.