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IFIT1 antibody
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Synonyms: | G10P1 antibody, GARG 16 antibody, IFI 56 antibody, IFI 56K antibody, IFI56 antibody, IFIT 1 antibody, IFIT1 antibody, IFNAI1 antibody, ISG56 antibody, RNM561 antibody | ||
Catalogue No.: | FNab04135 | Reativity: | Human, Rat, Mouse |
Host: | Rabbit | Tested Application: | ELISA, IHC, WB |
Clonality: | polyclonal | Isotype: | IgG |
- SPECIFICATIONS
- Product Name
- IFIT1 antibody
- Catalogue No.
- FNab04135
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- interferon-induced protein with tetratricopeptide repeats 1
- Alternative Names
- G10P1 antibody, GARG 16 antibody, IFI 56 antibody, IFI 56K antibody, IFI56 antibody, IFIT 1 antibody, IFIT1 antibody, IFNAI1 antibody, ISG56 antibody, RNM561 antibody
- UniProt ID
- P09914
- Observed MW
- 55 kDa
Application
- Tested Applications
- ELISA, IHC, WB
- Recommended dilution
- WB: 1:500-1:1000; IHC: 1:20-1:200
Validated Images
U-937 cells were subjected to SDS PAGE followed by western blot with FNab04135(IFIT1 Antibody) at dilution of 1:600
Immunohistochemistry of paraffin-embedded human breast cancer slide using FNab04135(IFIT1 Antibody) at dilution of 1:50
- Background
- Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group(PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation(cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.