Products

IFIT1 antibody

Synonyms:G10P1 antibody, GARG 16 antibody, IFI 56 antibody, IFI 56K antibody, IFI56 antibody, IFIT 1 antibody, IFIT1 antibody, IFNAI1 antibody, ISG56 antibody, RNM561 antibody
Catalogue No.:FNab04135Reativity:Human, Rat, Mouse
Host:RabbitTested Application:ELISA, IHC, WB
Clonality:polyclonalIsotype:IgG
  • SPECIFICATIONS
Product Name
IFIT1 antibody
Catalogue No.
FNab04135
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
interferon-induced protein with tetratricopeptide repeats 1
Alternative Names
G10P1 antibody, GARG 16 antibody, IFI 56 antibody, IFI 56K antibody, IFI56 antibody, IFIT 1 antibody, IFIT1 antibody, IFNAI1 antibody, ISG56 antibody, RNM561 antibody
UniProt ID
P09914
Observed MW
55 kDa
Application
Tested Applications
ELISA, IHC, WB
Recommended dilution
WB: 1:500-1:1000; IHC: 1:20-1:200
Validated Images
U-937 cells were subjected to SDS PAGE followed by western blot with FNab04135(IFIT1 Antibody) at dilution of 1:600
Immunohistochemistry of paraffin-embedded human breast cancer slide using FNab04135(IFIT1 Antibody) at dilution of 1:50
Background
Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group(PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation(cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.