anti- IDO1 antibody

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Product Information
Product name

anti- IDO1 antibody

Alternative name

IDO antibody, INDO antibody, IDO1 Antibody

Catalogue No.

FNab04127

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Description

IDO1 antibody: Rabbit Polyclonal antibody to IDO1

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)

Background

Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway(PubMed:17671174). Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses(PubMed:25691885). Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells(PubMed:25691885). Acts as a suppressor of anti-tumor immunity(PubMed:23103127, PubMed:25157255, PubMed:14502282, PubMed:25691885). Limits the growth of intracellular pathogens by depriving tryptophan(PubMed:25691885). Protects the fetus from maternal immune rejection(PubMed:25691885).

Immunogen Information
Immunogen

indoleamine 2,3-dioxygenase 1

Synonyms

CD107B, IDO, IDO 1, IDO1, INDO, indoleamine 2,3 dioxygenase 1

Calculated MW

42 kDa

Application
Specificity

Human, Rat

Tested Application

ELISA, IHC, WB

Recommended dilution

WB: 1:1000-1:4000; IHC: 1:50-1:500

Uniprot information
Gene Name

IDO1

Uniprot ID

P14902

Images

anti- IDO1 antibody 1

Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using FNab04127( IDO1 Antibody) at dilution of 1:100


anti- IDO1 antibody 1

Hela cells were subjected to SDS PAGE followed by western blot with FNab04127( IDO1 Antibody) at dilution of 1:2000

Current product's manual: Manual

Protocol may be updated. Please feel free to contact Finetest Team to acquire the latest version.

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027-87384275
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