Products
HEXA antibody
- Product Name
- HEXA antibody
- Catalogue No.
- FNab03842
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- hexosaminidase A (alpha polypeptide)
- Alternative Names
- HEXA antibody, Hexosaminidase subunit A antibody, TSD antibody
- UniProt ID
- P06865
- Observed MW
- 60 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Validated Images
PC-3 cells were subjected to SDS PAGE followed by western blot with FNab03842(HEXA antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded rat brain using FNab03842(HEXA antibody) at dilution of 1:100
- Background
- This gene encodes a member of the glycosyl hydrolase 20 family of proteins. The encoded preproprotein is proteolytically processed to generate the alpha subunit of the lysosomal enzyme beta-hexosaminidase. This enzyme, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene lead to an accumulation of GM2 ganglioside in neurons, the underlying cause of neurodegenerative disorders termed the GM2 gangliosidoses, including Tay-Sachs disease (GM2-gangliosidosis type I). Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.
