mouse liver tissue were subjected to SDS PAGE followed by western blot with FNab03805(HDAC8 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human breast cancer using FNab03805(HDAC8 Antibody) at dilution of 1:100
Background
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene.