SW480 cells were subjected to SDS PAGE followed by western blot with FNab03642(GRB2 Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded mouse kidney using FNab03642(GRB2 antibody) at dilution of 1:100
Background
The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.