anti- FOXA2 antibody

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Product Information
Product name

anti- FOXA2 antibody

Alternative name

HNF3B antibody, TCF3B antibody, FOXA2 Antibody

Catalogue No.

FNab03188

Size

100µg

Form

liquid

Purification

Immunogen affinity purified

Purity

≥95% as determined by SDS-PAGE

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Description

FOXA2 antibody: Rabbit Polyclonal antibody to FOXA2

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)

Background

Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a ‘pioneer’ factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5′-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3′ (By similarity) . In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.

Immunogen Information
Immunogen

forkhead box A2

Synonyms

forkhead box A2, Forkhead box protein A2, FOXA2, HNF 3 beta, HNF 3B, HNF3B, TCF 3B, TCF3B, Transcription factor 3B

Calculated MW

60 kDa

Application
Specificity

Human

Tested Application

ELISA, IP, WB, IHC

Recommended dilution

WB: 1:500-1:5000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:50-1:500

Uniprot information
Gene Name

FOXA2

Uniprot ID

Q9Y261

Images

anti- FOXA2 antibody 1

Immunohistochemistry of paraffin-embedded human pancreas tissue slide using FNab03188 (FOXA2 Antibody) at dilution of 1:50


anti- FOXA2 antibody 1

HepG2 cells were subjected to SDS PAGE followed by western blot with FNab03188 (FOXA2 Antibody) at dilution of 1:1000

Current product's manual: Manual

Protocol may be updated. Please feel free to contact Finetest Team to acquire the latest version.

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027-87384275
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