Products

FKBP1A antibody

Synonyms:FKBP1 antibody, FKBP12 antibody
Catalogue No.:FNab03136Reativity:Human, Mouse, Rat
Host:RabbitTested Application:ELISA, IHC, WB
Clonality:polyclonalIsotype:IgG
  • SPECIFICATIONS
Product Name
FKBP1A antibody
Catalogue No.
FNab03136
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
FK506 binding protein 1A, 12kDa
Alternative Names
FKBP1 antibody, FKBP12 antibody
UniProt ID
P62942
Observed MW
12 kDa
Application
Tested Applications
ELISA, IHC, WB
Recommended dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Validated Images
mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab03136( FKBP1A Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human ovary tumor using FNab03136(FKBP1A antibody) at dilution of 1:100
Background
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed.