Products

ERBB4 antibody

Synonyms:HER4 antibody
Catalogue No.:FNab02829Reativity:Mouse, Rat
Host:RabbitTested Application:ELISA, IHC, WB
Clonality:polyclonalIsotype:IgG
  • SPECIFICATIONS
Product Name
ERBB4 antibody
Catalogue No.
FNab02829
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
Alternative Names
HER4 antibody
UniProt ID
Q15303
Observed MW
180 kDa
Application
Tested Applications
ELISA, IHC, WB
Recommended dilution
WB: 1:500 - 1:1000; IHC: 1:50 - 1:100
Validated Images
mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab02829(ERBB4 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded rat lung using FNab02829(ERBB4 antibody) at dilution of 1:100
Background
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.