MCF7 cells were subjected to SDS PAGE followed by western blot with FNab02732(ELAC2 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human esophagus using FNab02732(ELAC2 antibody) at dilution of 1:100
Background
The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.