mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab02403(DKK3 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded rat heart using FNab02403( DKK3 Antibody) at dilution of 1:100
Background
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein.