MCF7 cells were subjected to SDS PAGE followed by western blot with FNab02374(DHRS9 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded mouse brain using FNab02374(DHRS9 antibody) at dilution of 1:100
Background
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. This protein demonstrates oxidoreductase activity toward hydroxysteroids and is able to convert 3-alpha-tetrahydroprogesterone to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone in the cytoplasm, and may additionally function as a transcriptional repressor in the nucleus. Alternative splicing results in multiple transcript variants.