A431 cells were subjected to SDS PAGE followed by western blot with FNab02207(KRT19 antibody) at dilution of 1:1500
Immunohistochemistry of paraffin-embedded human liver cancer using FNab02207( CK19 Antibody) at dilution of 1:200
Background
The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21.