mouse liver tissue were subjected to SDS PAGE followed by western blot with FNab02079(CUL4B antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human liver cancer using FNab02079(CUL4B antibody) at dilution of 1:100
Background
This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene.