HeLa cells were subjected to SDS PAGE followed by western blot with FNab02075( CUL3 Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human prostate using FNab02075(CUL3 antibody) at dilution of 1:100
Background
This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core component and scaffold protein of an E3 ubiquitin ligase complex. Complexes including the encoded protein may also play a role in late endosome maturation. Mutations in this gene are a cause of type 2E pseudohypoaldosteronism. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.