Products
COMT antibody
- Product Name
- COMT antibody
- Catalogue No.
- FNab01856
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- catechol-O-methyltransferase
- UniProt ID
- P21964
- Observed MW
- 28 kDa, 32 kDa
Application
- Tested Applications
- ELISA, IHC, IF, WB
- Recommended dilution
- WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200
Validated Images
mouse liver tissue were subjected to SDS PAGE followed by western blot with FNab01856( COMT Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded rat kidney using FNab01856(COMT antibody) at dilution of 1:100
- Background
- Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
