Products

Collagen Type I antibody

Synonyms:Alpha 2 type I collagen antibody, COL1A2 antibody, Collagen alpha 2(I) chain antibody, Collagen Type I antibody, collagen antibody, type I antibody, alpha 2 antibody, OI4 antibody
Catalogue No.:FNab01836Reativity:Human, Mouse, Rat
Host:RabbitTested Application:ELISA, WB, IHC
Clonality:polyclonalIsotype:IgG
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Product Name
Collagen Type I antibody
Catalogue No.
FNab01836
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
collagen, type I, alpha 2
Alternative Names
Alpha 2 type I collagen antibody, COL1A2 antibody, Collagen alpha 2(I) chain antibody, Collagen Type I antibody, collagen antibody, type I antibody, alpha 2 antibody, OI4 antibody
UniProt ID
P08123
Observed MW
118 kDa
Application
Tested Applications
ELISA, WB, IHC
Recommended dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Validated Images
mouse skin tissue were subjected to SDS PAGE followed by western blot with FNab01836(COL1A2 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded mouse brain tissue slide using FNab01836( COL1A2 Antibody) at dilution of 1:100
Background
This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.
Journal:
Modern Technologies in Medicine
Author:
Laboratory of Tissue Engineering, A. Tsyb Medical Radiological Research Centre — Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, 10 Zhukova St., Obninsk, 249036, Russia
Cited Date:
2023-05-12
Product: