Products

CDK4 antibody

Synonyms:CDK4 antibody, Cell division protein kinase 4 antibody, CMM3 antibody, cyclin dependent kinase 4 antibody, PSK J3 antibody
Catalogue No.:FNab01557Reativity:Human, Mouse, Rat
Host:RabbitTested Application:ELISA, WB, IHC, IF
Clonality:polyclonalIsotype:IgG
  • SPECIFICATIONS
Product Name
CDK4 antibody
Catalogue No.
FNab01557
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
cyclin-dependent kinase 4
Alternative Names
CDK4 antibody, Cell division protein kinase 4 antibody, CMM3 antibody, cyclin dependent kinase 4 antibody, PSK J3 antibody
UniProt ID
P11802
Observed MW
32 kDa
Application
Tested Applications
ELISA, WB, IHC, IF
Recommended dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:20 - 1:100
Validated Images
HeLa cells were subjected to SDS PAGE followed by western blot with FNab01557(CDK4 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using FNab01557( CDK4 Antibody) at dilution of 1:200
Background
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.