mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab00923(BMPR2 antibody) at dilution of 1:1000
IP Result of anti-BMPR2 (IP:FNab00923, 4ug; Detection:FNab00923 1:500) with mouse brain tissue lysate 6500ug.
Background
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6.