Products

Beclin 1 antibody

Synonyms:ATG6 antibody, Beclin 1 antibody, beclin 1 antibody, autophagy related antibody, beclin1 antibody, BECN1 antibody, GT197 antibody, Protein GT197 antibody, VPS30 antibody
Catalogue No.:FNab00860Reativity:Human, Mouse, Rat
Host:RabbitTested Application:ELISA, IHC, WB,IF
Clonality:polyclonalIsotype:IgG
  • SPECIFICATIONS
Product Name
Beclin 1 antibody
Catalogue No.
FNab00860
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
beclin 1, autophagy related
Alternative Names
ATG6 antibody, Beclin 1 antibody, beclin 1 antibody, autophagy related antibody, beclin1 antibody, BECN1 antibody, GT197 antibody, Protein GT197 antibody, VPS30 antibody
UniProt ID
Q14457
Observed MW
60 kDa
Application
Tested Applications
ELISA, IHC, WB,IF
Recommended dilution
WB: 1:500-1:5000; IHC: 1:20-1:200; IF: 1:20-1:200
Validated Images
MDA-MB-453s cells were subjected to SDS PAGE followed by western blot with FNab00860(Beclin 1 Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human colon cancer using FNab00860(Beclin 1 antibody) at dilution of 1:50
Immunofluorescent analysis of NIH/3T3 cells using Beclin 1 Antibody at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Background
Beclin-1(BECN1), also known as ATG6 or VPS30, has a central role in autophagy, a process of programmed cell survival, which is increased during periods of cell stress and extinguished during the cell cycle. Beclin-1, may play a role in antiviral host defense. It protects against infection by a neurovirulent strain of Sindbis virus. Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. A progressively reduced Beclin-1 expression is reported to correlate with the primary tumor growth of squamous cell carcinoma and adenocarcinoma of the lung. Caspase-mediated cleavage of Beclin 1 promotes crosstalk between apoptosis and autophagy.