Products

BCL2 antibody

Synonyms:Apoptosis regulator Bcl 2 antibody, B cell CLL/lymphoma 2 antibody, BCL2 antibody, Oncogene B cell leukemia 2 antibody
Catalogue No.:FNab00840Reativity:Human
Host:MouseTested Application:ELISA, WB, IP, IHC
Clonality:monoclonalIsotype:IgG2a
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Product Name
BCL2 antibody
Catalogue No.
FNab00840
Size
100μg
Form
liquid
Purification
Protein A+G purification
Purity
≥95% as determined by SDS-PAGE
Clonality
monoclonal
Isotype
IgG2a
Clone ID
8A10
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
B-cell CLL/lymphoma 2
Alternative Names
Apoptosis regulator Bcl 2 antibody, B cell CLL/lymphoma 2 antibody, BCL2 antibody, Oncogene B cell leukemia 2 antibody
UniProt ID
P10415
Observed MW
26 kDa
Application
Tested Applications
ELISA, WB, IP, IHC
Recommended dilution
WB: 1:1000-1:10000; IP: 1:500-1:5000; IHC: 1:100-1:2000
Validated Images
U-937 cells were subjected to SDS PAGE followed by western blot with FNab00840(BCL2 Antibody) at dilution of 1:6000
IP result of anti-BCL2(IP:FNab00840, 4ug; Detection:FNab00840 1:1000) with HL-60 cells lysate 4000 ug
Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using FNab00840(BCL2 Antibody) at dilution of 1:100
Background
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor(APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release(PubMed:17418785).
Journal:
Pharmacological Research - Modern Chinese Medicine
Author:
Microscopy and Stereology Research Unit, Department of Human Anatomy, Ahmadu Bello University, Zaria, Nigeria
Cited Date:
2024-02-23
Product: