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BCL2 antibody
- SPECIFICATIONS
- CITATIONS
- Product Name
- BCL2 antibody
- Catalogue No.
- FNab00840
- Size
- 100μg
- Form
- liquid
- Purification
- Protein A+G purification
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- monoclonal
- Isotype
- IgG2a
- Clone ID
- 8A10
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- B-cell CLL/lymphoma 2
- Alternative Names
- Apoptosis regulator Bcl 2 antibody, B cell CLL/lymphoma 2 antibody, BCL2 antibody, Oncogene B cell leukemia 2 antibody
- UniProt ID
- P10415
- Observed MW
- 26 kDa
Application
- Tested Applications
- ELISA, WB, IP, IHC
- Recommended dilution
- WB: 1:1000-1:10000; IP: 1:500-1:5000; IHC: 1:100-1:2000
Validated Images
U-937 cells were subjected to SDS PAGE followed by western blot with FNab00840(BCL2 Antibody) at dilution of 1:6000
IP result of anti-BCL2(IP:FNab00840, 4ug; Detection:FNab00840 1:1000) with HL-60 cells lysate 4000 ug
Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using FNab00840(BCL2 Antibody) at dilution of 1:100
- Background
- Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor(APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release(PubMed:17418785).
- Journal:
- Pharmacological Research - Modern Chinese Medicine
- Author:
- Microscopy and Stereology Research Unit, Department of Human Anatomy, Ahmadu Bello University, Zaria, Nigeria
- Cited Date:
- 2024-02-23
- Product: