MCF7 cells were subjected to SDS PAGE followed by western blot with FNab00669(ATG16L1 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human colon using FNab00669(ATG16L1 antibody) at dilution of 1:100
Background
The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene.