COS-7 cells were subjected to SDS PAGE followed by western blot with FNab00637(ASH2L antibody) at dilution of 1:1000
IP Result of anti-ASH2L (IP:FNab00637, 4ug; Detection:FNab00637 1:500) with COLO 320 cells lysate 2000ug.
Immunohistochemistry of paraffin-embedded human gliomas using FNab00637(ASH2L antibody) at dilution of 1:50
Background
Component of the Set1/Ash2 histone methyltransferase(HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis.