Products

ARHGEF1 antibody

Synonyms:ARHGEF1 antibody, GEF1 antibody, LBCL2 antibody, LSC antibody, P115 RHOGEF antibody, p115RhoGEF antibody, SUB1.5 antibody, ARHG1 antibody
Catalogue No.:FNab10091Reativity:Human, Rat
Host:RabbitTested Application:ELISA, IHC
Clonality:polyclonalIsotype:IgG
  • SPECIFICATIONS
Product Name
ARHGEF1 antibody
Catalogue No.
FNab10091
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
Rho guanine nucleotide exchange factor(GEF) 1
Alternative Names
ARHGEF1 antibody, GEF1 antibody, LBCL2 antibody, LSC antibody, P115 RHOGEF antibody, p115RhoGEF antibody, SUB1.5 antibody, ARHG1 antibody
UniProt ID
Q92888
Observed MW
102-110 kDa
Application
Tested Applications
ELISA, IHC
Recommended dilution
IHC: 1:20-1:200
Validated Images
Immunohistochemistry of paraffin-embedded rat lung using FNab10091(PER2 antibody) at dilution of 1:50
Background
Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12(GNA12) and alpha-13(GNA13) subunits. Acts as GTPase-activating protein(GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor(GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.