Products

APP antibody

Synonyms:A4 antibody, ABPP antibody, Alzheimer disease amyloid protein antibody, Cerebral vascular amyloid peptide antibody, Beta-amyloid precursor protein antibody, CVAP antibody, PreA4 antibody
Catalogue No.:FNab00512Reativity:Human, Mouse, Rat
Host:RabbitTested Application:ELISA, WB, IHC
Clonality:polyclonalIsotype:IgG
  • SPECIFICATIONS
Product Name
APP antibody
Catalogue No.
FNab00512
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
amyloid beta A4 precursor protein
Alternative Names
A4 antibody, ABPP antibody, Alzheimer disease amyloid protein antibody, Cerebral vascular amyloid peptide antibody, Beta-amyloid precursor protein antibody, CVAP antibody, PreA4 antibody
UniProt ID
P05067
Observed MW
110 kDa
Application
Tested Applications
ELISA, WB, IHC
Recommended dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:100
Validated Images
HeLa cells cells were subjected to SDS PAGE followed by western blot with FNab00512( APP Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human gliomas tissue slide using FNab00512( APP Antibody) at dilution of 1:100
Background
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.