Products
alpha-synuclein antibody
- Product Name
- alpha-synuclein antibody
- Catalogue No.
- FNab00345
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- synuclein, alpha (non A4 component of amyloid precursor)
- Alternative Names
- Alpha synuclein antibody, NACP antibody, PARK1 antibody, PARK4 antibody, SNCA antibody
- UniProt ID
- P37840
- Observed MW
- 15 kDa
Application
- Tested Applications
- ELISA, IHC, WB, IF
- Recommended dilution
- WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200
Validated Images
mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab00345(SNCA antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human brain using FNab00345(SNCA antibody) at dilution of 1:50
Immunofluorescent analysis of SH-SY5Y cells using FNab00345 (alpha-synuclein antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated Goat Anti-Rabbit IgG(H+L)
- Background
- Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene.
