Products

TGF-beta 1 antibody

Synonyms:CED antibody, DPD1 antibody, LAP antibody, TGF beta 1 antibody, TGFB antibody, TGFB1 antibody, TGFbeta antibody, TGF-beta1 antibody, TGF-β1 antibody
Catalogue No.:FNab08638Reativity:Human, Mouse, Rat
Host:RabbitTested Application:ELISA, WB, IHC
Clonality:polyclonalIsotype:IgG
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Product Name
TGF-beta 1 antibody
Catalogue No.
FNab08638
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
transforming growth factor, beta 1
Alternative Names
CED antibody, DPD1 antibody, LAP antibody, TGF beta 1 antibody, TGFB antibody, TGFB1 antibody, TGFbeta antibody, TGF-beta1 antibody, TGF-β1 antibody
UniProt ID
P01137?
Observed MW
44 kDa
Application
Tested Applications
ELISA, WB, IHC
Recommended dilution
WB: 1:200-1:2000; IHC: 1:50-1:500
Validated Images
A549 cells were subjected to SDS PAGE followed by western blot with FNab08638(TGFB1 Antibody) at dilution of 1:600
Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using FNab08638(TGFB1 Antibody) at dilution of 1:200
Background
TGFB, also named as LAP and TGFB1, is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. TGFB acts synergistically with TGFA in inducing transformation. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result in apoptosis. Many cells synthesize TGFB and almost all of them have specific receptors for it. TGFB positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. It is highly expressed in bone. Mutation of TGFB are the cause of Camurati-Engelmann disease(CED) which known as progressive diaphyseal dysplasia 1(DPD1).