Products

Caspase 12 antibody

Synonyms:CASP12 antibody, CASP-12 antibody, CASP12P1 antibody
Catalogue No.:FNab01286Reativity:Human, Mouse, Rat
Host:RabbitTested Application:ELISA, IF, IHC, WB, IP
Clonality:polyclonalIsotype:IgG
  • SPECIFICATIONS
Product Name
Caspase 12 antibody
Catalogue No.
FNab01286
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
caspase 12(gene/pseudogene)
Alternative Names
CASP12 antibody, CASP-12 antibody, CASP12P1 antibody
UniProt ID
Q6UXS9
Observed MW
36-42 kDa, 50 kDa
Application
Tested Applications
ELISA, IF, IHC, WB, IP
Recommended dilution
WB: 1:500-1:2000; IP: 1:500-1:1000; IHC: 1:20-1:200; IF: 1:10-1:100
Validated Images
Various lysates were subjected to SDS PAGE followed by western blot with FNab01286(CASP12 antibody) at dilution of 1:1000
IP Result of anti-Caspase 12 (IP:FNab01286, 4ug; Detection:FNab01286 1:1000) with HEK-293 cells lysate 2000ug.
Immunohistochemistry of paraffin-embedded human prostate hyperplasia tissue slide using FNab01286(Caspase 12 Antibody) at dilution of 1:200
Background
Caspase 12 is an enzyme known as a cysteine protease. It belongs to a family of enzymes called caspases that cleave their substrates at C-terminal aspartic acid residues. It is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. Caspase-12 is located in the endoplasmic reticulum (ER). It is responsible for ER-stress-induced apoptosis, such as high calcium concentration, low oxygen and low glucose levels. This antibody detects endogenous levels of full-length caspase-12 protein (50 kDa) and its cleaved product (40-44 kDa).