Products
USP20 antibody
- Product Name
- USP20 antibody
- Catalogue No.
- FNab09317
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- ubiquitin specific peptidase 20
- Alternative Names
- Deubiquitinating enzyme 20 antibody, hVDU2 antibody, KIAA1003 antibody, LSFR3A antibody, Ubiquitin thiolesterase 20 antibody, USP20 antibody, VDU2 antibody
- UniProt ID
- Q9Y2K6
- Observed MW
- 110 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IP
- Recommended dilution
- WB: 1:200-1:2000; IHC: 1:20-1:200；IP: 1:200-1:2000
Validated Images
HepG2 cells were subjected to SDS PAGE followed by western blot with FNab09317(USP20 antibody) at dilution of 1:400
IP Result of anti-USP20 (IP:FNab09317, 4ug; Detection:FNab09317 1:500) with HeLa cells lysate 1200ug.
Immunohistochemistry of paraffin-embedded human kidney using FNab09317(USP20 antibody) at dilution of 1:50
- Background
- Deubiquitinating enzyme involved in beta-2 adrenergic receptor(ADRB2) recycling. Acts as a regulator of G-protein coupled receptor(GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor(ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'-and 'Lys-63'-linked polyubiquitin chains.
