Products

UBD antibody

Synonyms:Diubiquitin antibody, FAT10 antibody, GABBR1 antibody, UBD antibody, UBD 3 antibody, ubiquitin D antibody, Ubiquitin like protein FAT10 antibody
Catalogue No.:FNab09160Reativity:Human, Mouse, Rat
Host:RabbitTested Application:ELISA, WB, IHC
Clonality:polyclonalIsotype:IgG
  • SPECIFICATIONS
Product Name
UBD antibody
Catalogue No.
FNab09160
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
ubiquitin D
Alternative Names
Diubiquitin antibody, FAT10 antibody, GABBR1 antibody, UBD antibody, UBD 3 antibody, ubiquitin D antibody, Ubiquitin like protein FAT10 antibody
UniProt ID
O15205
Observed MW
18 kDa
Application
Tested Applications
ELISA, WB, IHC
Recommended dilution
WB: 1:500-1:5000; IHC: 1:20-1:200
Validated Images
human stomach tissue were subjected to SDS PAGE followed by western blot with FNab09160(UBD antibody) at dilution of 1:300
Immunohistochemistry of paraffin-embedded human colon cancer using FNab09160(UBD antibody) at dilution of 1:100
Background
Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1L-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9(PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells(RTECs). May be involved in dendritic cell(DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease and Human immunodeficiency virus(HIV)-associated nephropathy(HIVAN).