Products
RSPO3 antibody
- Product Name
- RSPO3 antibody
- Catalogue No.
- FNab07512
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- R-spondin 3 homolog
- Alternative Names
- CRISTIN1 antibody, hPWTSR antibody, hRspo3 antibody, Protein with TSP type 1 repeat antibody, PWTSR antibody, R spondin 3 antibody, Roof plate specific spondin 3 antibody, RSPO3 antibody, THSD2 antibody
- UniProt ID
- Q9BXY4
- Observed MW
- 40 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:200-1:1000; IHC: 1:100-1:400
Validated Images
mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab07512(RSPO3 Antibody) at dilution of 1:300
Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using FNab07512(RSPO3 Antibody) at dilution of 1:200
- Background
- Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6(LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway(PubMed:21727895, PubMed:21909076, PubMed:22615920). Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells(By similarity).
