Products
MAP3K3 antibody
- Product Name
- MAP3K3 antibody
- Catalogue No.
- FNab09784
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- mitogen-activated protein kinase kinase kinase 3
- Alternative Names
- MAP3K3 antibody, MAPK/ERK kinase kinase 3 antibody, MAPKKK3 antibody, MEK kinase 3 antibody, MEKK 3 antibody, MEKK3 antibody
- UniProt ID
- Q99759
- Observed MW
- 74 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:200-1:2000; IHC: 1:50-1:500
Validated Images
HepG2 cells were subjected to SDS PAGE followed by western blot with FNab09784(MAP3K3 Antibody) at dilution of 1:300
Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using FNab09784(MAP3K3 Antibody) at dilution of 1:100
- Background
- The mitogen-activated protein/ERK kinase kinase 3(MEKK3) is a member of a family of MEKK/Ste11 serine/threonine protein kinases. One function of MEKK3 is to serve as an upstream regulatory kinase in the mitogen-activated protein kinase cascade, however, it also plays a critical role in other signaling pathways. MEKK3 regulates several important functions including cell survival and proliferation. It is ubiquitously expressed in multiple tissues and has been found in complexes with scaffold proteins and other kinases.(PMID: 18206350).Cerebral cavernous malformations(CCMs) complex regulation of MEKK3 is essential during vertebrate heart development. MEKK3 signalling and KLF2/4 may be targeted to develop new CCM therapeutics.
