Large envelope protein antibody, Large surface protein antibody, Large S protein antibody, Major surface antigen antibody
Catalogue No.：
HBV001
Reactivity：
Human
Host：
Mouse
Tested Application：
ELISA, test strip
Clonality：
monoclonal
Isotype：
IgG2a
SPECIFICATIONS
Product Name
HBsAg mouse antibody
Catalogue No.
HBV001
Size
100μg
Form
liquid
Purification
Protein A+G purification
Purity
≥95% as determined by SDS-PAGE
Clonality
monoclonal
Isotype
IgG2a
Clone ID
4A10
Storage
20mM PBS, 0.1% proclin300, store at 2-8°C up to 21 days, -20°C for long-term storage. Don't repeated freeze-thaw.
Immunogen
Immunogen
HBsAg
Alternative Names
Large envelope protein antibody, Large surface protein antibody, Large S protein antibody, Major surface antigen antibody
Observed MW
43 kDa
Application
Tested Applications
ELISA, test strip
Background
The large envelope protein exists in two topological conformations, one which is termed 'external' or Le-HBsAg and the other 'internal' or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This interaction determines the species specificity and liver tropism. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis. The large envelope protein also assumes fusion between virion membrane and endosomal membrane(Probable). In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein.
